RETICULOCYTOGRAM IN PATIENTS WITH SICKLE CELL ANEMIA AND HEMOGLOBIN SC DISEASE

Abstract

This work evaluated the erythropoetic behavior of two common hemoglobin SS and SC, using automated reticulocytogram in Sysmex XT 2100, between 1 to 14 years old patients. The group of hemoglobin SS patients showed more intense medullar activity, with higher reticulocytes counting (17% in average) and increase on youngest cell fractions. The SC patients showed high counting in relation to the control group and profile of the reticulocyte fractions congruous of a chronic hemolytic picture, quite different from SS group. The results showed a very characteristic profile in each group and these profiles allowed a laboratory differentiation among the groups. The results are in agreement with other authors, and open perspectives for similar studies, since the knowledge of automated reticulocytogram for the diverse erythrocyte illness is of great clinical importance.